April 12 2021, LA Times

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Clue
Soothing ointment
Criticize harshly
Deep-voiced singer
Great Lake that stretches from New York to Michigan
Every 12 mos.
Significant __: partner
Place for junk
Genetic twin
"Honey, I'm Home" singer Twain
Wagons at midday socials
B and B's, e.g.
Home of twigs
Did a marathon, say
Relaxation of govt. rules
Skip, with "out"
Turn loose
Annoys
Oft-stubbed digit
In time gone by
U.S. Congress, informally
Enjoyed a meal
Web or nanny follower
Reef makeup
Some youth ctrs.
Cotton gin inventor Whitney
Defy authority
Approves
Dimpled facial feature, perhaps
Game room missile
From Tokyo, say
Overly large
Still in the game
Increasing, and a hint to 17- and 40-Across and 11- and 27-Down
Distance runner
Prescription amount
"Enchanted" movie girl played by Anne Hathaway
Arterial implant
Seeks answers
Doe or stag
"Porgy and __"
Half a McDonald's logo
Old Italian money
Definition
Manually
"__ you comfy?"
Venetian blind piece
Promote big-time
Italian lawn bowling
Book of maps
Small order of pancakes
FedExed, say
Unrefined minerals
ATM code
__-hair pasta
Extremely harsh
Fit for a monarch
Nuclear reactor
Get-well program, briefly
Banished from one's country
Greek i's
Golfer's pegs
Doily trim
Needing no Rx
Like a fox, it's said
Lena who sang "Stormy Weather"
Took a drive
Wood-shaping machines
Place of refuge
Chemically nonreactive
Fish eggs
Traffic tie-ups
Touched down
Ginger ale or root beer
"The Catch" actress Mireille __
Liver secretion
Shipwreck site
Stick shift choice
"Shame on you!"