The clue "Be effective" was last spotted by us at the New York Times Crossword on June 3 2020.
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|James who sang "At last, my love has come along"|
|Things with nails sticking out|
|Fat removal procedure, in brief|
|Direction on a ship|
|Homecoming returnee, for short|
|During the recent past|
|Airy snack item|
|Like Life Savers|
|Miss Piggy's coy question|
|Having ___ of it|
|"Pretty Woman" co-star|
|Singer whose 1980 single "The Breaks" was the first gold record rap song|
|Fairy tale villain associated with the ends of 20-, 27- and 49-Across|
|"Je t'___" ("I love you," in French)|
|Home of Timbuktu|
|M.R.I., for one|
|If you drop this, you're sure to trip|
|What hot dogs do|
|Parts of gym routines|
|Org. with monitors|
|Many a middle schooler|
|On the main|
|Makes too busy to do other things|
|It "monthly changes in her circled orb," in "Romeo and Juliet"|
|Up and ___|
|Crisp, smooth fabric|
|Explorer ___ da Gama|
|Title role for Michael Caine and Jude Law|
|As of now|
|Starting point for a German count|
|Almost any word ending in -ize|
|___ Haley, former U.N. ambassador|
|Alternative to "com" and "org"|
|Mend, as a torn seam|
|All of America wrapped up in one book|
|Way, way up|
|Type of coffee|
|Theatrical partner of "Arsenic"|
|Set to the right or the left|
|Agcy. for retirees|
|Things shown to bouncers|